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4-Nitro-2-phenoxyphenol

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4-Nitro-2-phenoxyphenol Basic information

Product Name:
4-Nitro-2-phenoxyphenol
Synonyms:
  • 4-Nitro-2-phenoxyphenol
  • Phenol, 4-nitro-2-phenoxy-
  • 4-Nitro-2-phenoxyphenol (Nimesulide Impurity)
CAS:
70995-08-3
MF:
C12H9NO4
MW:
231.2
Mol File:
70995-08-3.mol
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4-Nitro-2-phenoxyphenol Chemical Properties

Melting point:
63℃ (ligroine )
Boiling point:
358.2±37.0 °C(Predicted)
Density 
1.357±0.06 g/cm3(Predicted)
storage temp. 
-20°C, Inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
5.76±0.16(Predicted)
color 
Pale Yellow to Light Yellow
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4-Nitro-2-phenoxyphenol Usage And Synthesis

Uses

4-?Nitro-?2-?phenoxyphenol is a impurity of Nimesulide (N477500), antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Also used in the preparation of benzoxirenes and the synthesis of trioxonins.

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