GanoMycin I Chemical Properties

Boiling point:

521.5±50.0 °C(Predicted)

Density 

1.135±0.06 g/cm3(Predicted)

pka

9.68±0.48(Predicted)

GanoMycin I Usage And Synthesis

Uses

Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects[1][2].

References

[1] Tran PT, et, al. Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1. Phytomedicine. 2019 Mar 1;55:1-8. DOI:10.1016/j.phymed.2018.10.029
[2] Wang K, et, al. Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo. J Med Chem. 2018 Apr 26;61(8):3609-3625. DOI:10.1021/acs.jmedchem.8b00107

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