SAR-020106
SAR-020106 Basic information
- Product Name:
- SAR-020106
- Synonyms:
-
- SAR-020106
- (R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile
- 5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile
- SAR-020106 >=95%
- SAR 20106
- SAR020106; SAR020106; SAR 020106; SAR20106; SAR20106; SAR 20106
- SAR20106
- 2-Pyrazinecarbonitrile, 5-[(8-chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-
- CAS:
- 1184843-57-9
- MF:
- C19H19ClN6O
- MW:
- 382.85
- Mol File:
- 1184843-57-9.mol
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SAR-020106 Chemical Properties
- form
- Solid
- color
- Off-white to light yellow
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SAR-020106 Usage And Synthesis
Uses
5-[(8-Chloro-3-isoquinolinyl)amino]-3-[(1R)-2-(dimethylamino)-1-methylethoxy]-2-pyrazinecarbonitrile is a potent and selective CHK1 inhibitor. CHK1 is a serine/threonine kinase involved with DNA damage repair and cell cycle arrest.
in vivo
SAR-020106 (40 mg/kg; i.p.; administered on days 0, 1, 7, 8, 14, and 15) in combination with Irinotecan potentiates the antitumor activity in SW620 xenografts[1].
| Animal Model: | Nude mice bearing SW620 xenograft tumors[1] |
| Dosage: | 40 mg/kg |
| Administration: | I.p.; administered on days 0, 1, 7, 8, 14, and 15 |
| Result: | There was a clear decrease in tumor growth associated with the combination with tumors reaching 300% by 12.5 days. |
IC 50
Chk1: 13.3 nM (IC50)
SAR-020106Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Twochem Co.Ltd
- Tel
- 021-021-58111628 15800915896
- sales@twochem.com