ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Epigenetics > Histone Demethylase inhibitors > ML234
ML234
ML234 Basic information
- Product Name:
- ML234
- Synonyms:
-
- ML234
- ML324
- ML243
- N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide
- NCGC00183808-01
- ML324(CID-44143209)
- CS-2198
- ML-324;ML324;ML 324
- CAS:
- 1222800-79-4
- MF:
- C21H23N3O2
- MW:
- 349.43
- Product Categories:
-
- Inhibitors
- Mol File:
- 1222800-79-4.mol
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ML234 Chemical Properties
- Melting point:
- >187oC (dec.)
- Boiling point:
- 590.1±50.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- pka
- 4.71±0.40(Predicted)
- color
- white to light brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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ML234 Usage And Synthesis
Description
ML324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the latent state in sensory neurons.1
Uses
ML324 is a JMJD2 demethylase inhibitor. It blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.
References
1) Liang?et al. (2013),?Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency; Sci. Transl. Med.,?5?167ra5
ML234Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
TargetMol Chemicals Inc.
- Tel
- 021-33632979 15002134094
- marketing@targetmol.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn