2-Chloropyrimidine Chemical Properties

Melting point:

63-66 °C (lit.)

Boiling point:

75-76 °C/10 mmHg (lit.)

Density 

1.2710 (rough estimate)

refractive index 

1.5320 (estimate)

Flash point:

98 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Methanol, Water

pka

-1.46±0.13(Predicted)

form 

Crystals or Crystalline Powder

color 

Yellow to pale orange

Water Solubility 

Slightly soluble in water. 33.3 mg soluble in 1 mL of alcohol.

Sensitive 

Moisture Sensitive

BRN 

107171

InChIKey

UNCQVRBWJWWJBF-UHFFFAOYSA-N

CAS DataBase Reference

1722-12-9(CAS DataBase Reference)

NIST Chemistry Reference

Pyrimidine, 2-chloro-(1722-12-9)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36-36/38-36/37/38

Safety Statements 

26-37/39-36

RIDADR 

2811

WGK Germany 

3

F 

10-23

Hazard Note 

Irritant

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:2-Chloropyrimidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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2-Chloropyrimidine Usage And Synthesis

Chemical Properties

yellowish to pale orange crystals or cryst. powder

Uses

2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.

Uses

2-Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds. It was used in the synthesis of 4?-(1,1?-(5-(2-methoxyphenoxy)-[2,2?-bipyrimidine]-4,6-diyl)bis(1H-pyrazol-3,1-diyl)) dianiline fluorescent dye, biosensor for protein assay, 2-amino-4-heteroarylpyrimidines, cis- and trans-octahydropyrrolo[2,3]pyridine derivatives.

General Description

2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.

Purification Methods

It has been recrystallised from *C6H6, pet ether or a mixture of both. It sublimes at 50o/18mm and can be distilled in a vacuum. [IR: Short & Thompson J Chem Soc 168 1952, Boarland & McOmie J Chem Soc 1218 1951, Beilstein 23/5 V 343.]

2-Chloropyrimidine(1722-12-9)Related Product Information

• Silver sulfadiazine
• 5-Bromo-2-chloropyrimidine
• Trimethoprim
• Fluorocytosine
• Uracil
• Sulfadiazine
• Cytosine
• 2-Cyanopyrimidine
• 2-(1-Piperazinyl)pyrimidine
• 2,6-Dichloro-7-methylpurine
• 2,4,6-Trichloropyrimidine
• 2-Chloroadenosine
• 2,4-Dichloro-5-methylpyrimidine
• 2,4-Dichloro-6-methyl-5-nitropyrimidine
• 2,4-Dichloro-6,7-dimethoxyquinazoline
• 2,4,5,6-TETRACHLOROPYRIMIDINE
• 2-Chloro-4,6-dimethylpyrimidine
• 2,6-Dichloropurine