8-Hydroxyquinoline sulfate Chemical Properties

Melting point:

~175 °C

Density 

1.3819 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5364 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

crystalline

color 

yellow

Water Solubility 

>=10 g/100 mL at 19 ºC

Merck 

14,4843

BRN 

3760550

InChIKey

MRUMAIRJPMUAPZ-UHFFFAOYSA-N

LogP

2.42 at 25℃

CAS DataBase Reference

134-31-6(CAS DataBase Reference)

EPA Substance Registry System

8-Quinolinol sulfate (134-31-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

RIDADR 

2811

WGK Germany 

1

RTECS 

VC8260000

F 

3-10

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29339900

MSDS

• Language:English Provider:Bis(8-hydroxyquinolinium) sulphate
• Language:English Provider:SigmaAldrich

8-Hydroxyquinoline sulfate Usage And Synthesis

Chemical Properties

Crystalline

Originator

Chinosol,Chinosolfabrik

Uses

Pharmaceutic aid (complexing agent).

Uses

oxyquinoline sulfate is a disinfectant and a preservative against fungus growth. It is made from phenols.

Uses

8-Hydroxyquinoline sulfate is used to control grey mould (Botrytis cinevea) in vine grafting. It is also used as a soil sterilant against damping off in seed beds.

Manufacturing Process

The mixture of 1.4 kg o-nitrophenol, 2.1 kg o-aminophenol, 6 kg glycerine (d = 1.26) and 5 kg sulfuric acid (d = 1.848) was heated at reflux to temperature 130°-140°C. This temperature was kept for 1.5 hours. The obtained oxyquinoline precipitated, the liquid was removed with water-steam distillation. The residue was diluted with water and alkalized with sodium hydroxide and sodium carbonate to the strong alkaline reaction. The repeated distillation with water steam gave the oil, which hardened as the long needles by cooling. MP: 75°-76°C recrystallized from diluted ethanol.
In practice it is usually used as sulfate salt

Therapeutic Function

Antiseptic

General Description

Pale yellow to yellow crystalline powder with a slight saffron odor. Burning taste.

Air & Water Reactions

Water soluble.

Reactivity Profile

A sulfate acidic salt of an amine that is also a phenol. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Fire Hazard

Flash point data for 8-Hydroxyquinoline sulfate are not available, but 8-Hydroxyquinoline sulfate is probably combustible.

Flammability and Explosibility

Not classified

Metabolic pathway

Little published information is available.

Degradation

The salt and free base of 8-hydroxyquinoline sulfate are very stable but alkali liberates quinolin-8-ol which precipitates heavy metals (PM). 8-Hydroxyquinoline is a chelate ligand of transition metals such as copper.

8-Hydroxyquinoline sulfate(134-31-6)Related Product Information

• Atropine sulfate
• Kanamycin sulfate
• 8-Hydroxyquinoline
• Aluminum sulfate
• Copper quinolate
• SODIUM SULFATE
• Ammonium sulfate
• Magnesium sulfate heptahydrate
• Magnesium sulfate
• D-Glucosamine sulfate
• Colistin sulfate
• Neomycin sulfate
• SULFATE STANDARD
• Sodium sulfate
• 8-Hydroxyquinoline aluminum salt
• Quinhydrone
• Barium sulfate
• Dimethyl sulfate