1-TRIMETHYLSILYLMETHANOL Chemical Properties

Melting point:

<0°C

Boiling point:

120-122 °C754 mm Hg(lit.)

Density 

0.826 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.419(lit.)

Flash point:

88 °F

storage temp. 

2-8°C

form 

clear liquid

pka

15.92±0.10(Predicted)

Specific Gravity

0.827

color 

Colorless to Almost colorless

Water Solubility 

Fully miscible in water.

Hydrolytic Sensitivity

1: no significant reaction with aqueous systems

BRN 

1731486

CAS DataBase Reference

3219-63-4(CAS DataBase Reference)

EPA Substance Registry System

Methanol, (trimethylsilyl)- (3219-63-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 1987 3/PG 3

WGK Germany 

3

RTECS 

PC4100000

TSCA 

Yes

HS Code 

2931.90.9010

HazardClass 

3

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-TRIMETHYLSILYLMETHANOL Usage And Synthesis

Uses

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Purification Methods

If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.]

1-TRIMETHYLSILYLMETHANOL(3219-63-4)Related Product Information

• 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
• TRIMETHYLSILYL DIETHYLPHOSPHONOACETATE
• (TRIMETHYLSILYL)CYCLOPENTADIENE, MIXTURE OF ISOMERS
• TRIMETHYLSILYL PROPIONATE
• TRIMETHYLSILYL TRIFLUOROACETATE
• 1-TRIMETHYLSILYLMETHANOL
• (TRIMETHYLSILYL)METHYL TRIFLUOROMETHANESULFONATE
• 1-(TRIMETHYLSILYL)ETHANOL, 98
• (METHOXYMETHYL)TRIMETHYLSILANE
• (1-ETHOXYVINYL)-TRIMETHYLSILANE
• ACRYLOXYMETHYLTRIMETHYLSILANE
• (PHENYLDIMETHYLSILYL)METHYL METHACRYLATE
• (1-HYDROXYALLYL)TRIMETHYLSILANE
• 1-TRIETHYLSILYL-4-(TRIETHLYLSILYLOXY)-1-BUTYNE
• METHACRYLOXYMETHYLTRIMETHYLSILANE
• (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine
• (1-METHOXYVINYL)TRIMETHYLSILANE
• TRIMETHYLSILYLMETHYL ACETATE