(+)-AEROPLYSININ-1
(+)-AEROPLYSININ-1 Basic information
- Product Name:
- (+)-AEROPLYSININ-1
- Synonyms:
-
- (+)-aeroplysinini
- (1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit
- 4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr
- aeroplysinini
- AEROPLYSININ
- (+)-AEROPLYSININ-1
- (+)-AEROPLYSININ-1, APLYSINA AEROPHOBA
- AEROPLYSININ, APLYSINA AEROPHOBA
- CAS:
- 28656-91-9
- MF:
- C9H9Br2NO3
- MW:
- 338.98
- Mol File:
- 28656-91-9.mol
(+)-AEROPLYSININ-1 Chemical Properties
- Boiling point:
- 479.6±45.0 °C(Predicted)
- Density
- 2.01±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol: Soluble
- form
- A solid
- pka
- 10.54±0.70(Predicted)
(+)-AEROPLYSININ-1 Usage And Synthesis
Description
(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.
Uses
(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.
Definition
ChEBI: Aeroplysinin 1 is a tertiary alcohol.
(+)-AEROPLYSININ-1Supplier
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(+)-AEROPLYSININ-1(28656-91-9)Related Product Information
- (+)-Aeroplysinin-1, Aplysina areophoba,(+)-Aeroplysinin-1, Aplysina areophoba
- 3-HYDROXY-3-METHYLBUTYRONITRILE
- 5-Bromo-1-pentene
- 5-Hexenenitrile
- (R)-(-)-3-HYDROXYBUTYRONITRILE
- (S)-3-Bromo-1,2-propanediol
- 5-BROMOVALERONITRILE
- (E)-2-BROMO-2-BUTEN-1-OL
- (+)-AEROPLYSININ-1
- 3-Bromo-3-buten-1-ol
- 1,3-DIBROMO-1-PROPENE
- 1-cyano-2-hydroxy-3-butene
- (S)-(+)-3-HYDROXYBUTYRONITRILE
- 5-Bromohex-5-enenitrile