1-Chloro-3-iodobenzene Chemical Properties

Melting point:

95-96 °C

Boiling point:

103-104 °C15 mm Hg(lit.)

Density 

1.926 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.631(lit.)

Flash point:

215 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Liquid

Specific Gravity

1.926

color 

Clear light yellow

Water Solubility 

Soluble in water 67.2 mg/L.

Sensitive 

Light Sensitive

BRN 

1904539

CAS DataBase Reference

625-99-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-chloro-3-iodo-(625-99-0)

EPA Substance Registry System

Benzene, 1-chloro-3-iodo- (625-99-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29039990

MSDS

• Language:English Provider:3-Chloroiodobenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Chloro-3-iodobenzene Usage And Synthesis

Chemical Properties

Clear light yellow liquid

Uses

suzuki reaction

Uses

1-Chloro-3-iodobenzene is used as a pharmaceutical intermediate.

Synthesis Reference(s)

Synthetic Communications, 11, p. 639, 1981 DOI: 10.1080/00397918108063637

General Description

The multiple-quantum proton NMR spectra of 3-chloroiodobenzene was studied.

Synthesis

General procedure for the synthesis of m-chloroiodobenzene from 3-chlorophenylboronic acid: a mixture of arylboronic acid (0.55 mmol), KF (96 mg, 1.65 mmol) and I2 (127 mg, 0.50 mmol) in 1,4-dioxane (5 mL) was stirred and reacted for 1 hr at 80 °C. After completion of the reaction, the mixture was filtered through a silica gel column and eluted with ether (10 mL). Subsequently, the solvent was removed by rotary evaporator. For further purification, the target product, m-chloroiodobenzene, was isolated by silica gel column chromatography using petroleum ether/ether (98:2) as eluent.

References

[1] Chemistry - A European Journal, 2011, vol. 17, # 20, p. 5652 - 5660
[2] Tetrahedron Letters, 2015, vol. 56, # 9, p. 1122 - 1123
[3] Synlett, 1998, # 2, p. 141 - 142
[4] Synlett, 2014, vol. 25, # 7, p. 995 - 1000

1-Chloro-3-iodobenzene(625-99-0)Related Product Information

• 1-Bromo-4-iodobenzene
• 4-Iodoanisole
• (Diacetoxyiodo)benzene
• 3-Chlorobenzyl chloride
• 3-Chloroperoxybenzoic acid
• 1,4-Diiodobenzene
• Iodobenzene
• 3-Chloroaniline
• 1,4-DICHLORO-2-IODOBENZENE
• 4-CHLORO-2-IODOANISOLE
• Clioquinol
• 1-Methyl-2-chloro-4-iodobenzene
• 3-CHLORO-4-FLUOROIODOBENZENE
• 1,2-Dichloro-3-iodobenzene
• 4-CHLORO-2-IODOTOLUENE
• 3,4-Dichloroiodobenzene
• Difluorochloromethane
• 2-CHLORO-1,3-DIFLUORO-4-IODOBENZENE