Estradiol Chemical Properties

Melting point:

176-180 °C(lit.)

alpha 

D20 +53 to +56° (c = 0.9 in dioxane)

Boiling point:

355.44°C (rough estimate)

Density 

1.0708 (rough estimate)

refractive index 

1.4800 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

ethanol: 50 mg/mL, clear, colorless

form 

powder

pka

10.27±0.60(Predicted)

color 

white with slight yellow

Water Solubility 

3.9mg/L(25 ºC)

Merck 

14,3704

CAS DataBase Reference

57-91-0(CAS DataBase Reference)

NIST Chemistry Reference

Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)

EPA Substance Registry System

Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

45-48-40

Safety Statements 

53-45-24/25-22

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

KG3750000

F 

8-10

HS Code 

29372390

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Estradiol Usage And Synthesis

Chemical Properties

White Solid

Uses

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Definition

ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).

Biological Activity

Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

target

Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor

storage

Room temperature

Purification Methods

17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Estradiol(57-91-0)Related Product Information

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