PROSTAGLANDIN H2 Chemical Properties

Boiling point:

490.1±40.0 °C(Predicted)

Density 

1.129±0.06 g/cm3(Predicted)

Flash point:

-17 °C

storage temp. 

−70°C

solubility 

Ethanol: >100 mg/ml; PBS pH 7.2: >2 mg/ml

form 

acetone solution

pka

4.76±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36-66-67

Safety Statements 

9-16-26

RIDADR 

UN 1090 3/PG 2

WGK Germany 

1

MSDS

• Language:English Provider:SigmaAldrich

PROSTAGLANDIN H2 Usage And Synthesis

Description

Prostaglandin H₂ (PGH₂) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor. PGH₂ is the precursor for all 2-series PGs and thromboxanes (TXs), and is a TP receptor agonist which irreversibly aggregates human platelets at 50-100 ng/ml.

Uses

PGH2 (Prostaglandin H2) is a thromboxane A2 precursor and a platelet aggregator of vascular smooth muscle contraction.

Definition

ChEBI: Prostaglandin H2 is an oxylipin, an olefinic compound, a secondary alcohol and a prostaglandins H. It has a role as a mouse metabolite. It is a conjugate acid of a prostaglandin H2(1-).

References

[1] M HAMBERG. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1974, 71 2: 345-349. DOI: 10.1073/pnas.71.2.345
[2] KATE?INA MACáKOVá . In vitro platelet antiaggregatory properties of 4-methylcoumarins[J]. Biochimie, 2012, 94 12: Pages 2681-2686. DOI: 10.1016/j.biochi.2012.09.006

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