4-Nitrobenzenesulfonyl chloride Chemical Properties

Melting point:

75 °C

Boiling point:

143-144 °C (1.5002 mmHg)

Density 

1.602 (estimate)

vapor pressure 

0.009Pa at 20℃

refractive index 

1.6000 (estimate)

Flash point:

143-144°C/1.5mm

storage temp. 

Store below +30°C.

solubility 

soluble in Toluene

form 

Powder

color 

yellow

PH

1 (H2O, 20℃)

Water Solubility 

Insoluble

Sensitive 

Moisture Sensitive

BRN 

746543

Stability:

Moisture Sensitive

LogP

2.1 at 20℃

CAS DataBase Reference

98-74-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Nitrobenzenesulphonyl chloride(98-74-8)

EPA Substance Registry System

Benzenesulfonyl chloride, 4-nitro- (98-74-8)

Safety Information

Hazard Codes 

C

Risk Statements 

34-52/53

Safety Statements 

26-36/37/39-45-61

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

21

Hazard Note 

Corrosive/Moisture Sensitive

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049085

MSDS

• Language:English Provider:4-Nitrobenzene-1-sulfonyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Nitrobenzenesulfonyl chloride Usage And Synthesis

Chemical Properties

yellow to brown powder

Uses

4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2'-bipyridine, nbs = 4-nitrobenzenesulfonate).

Uses

4-Nitrobenzenesulfonyl chloride was used in the synthesis of

• [Cu(bipy)₂Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate)
• hydroxylamines of sulfadiazine and sulfamethoxazole
• solution phase peptide using N-nosyl-α-amino acids.

Uses

4-Nitrobenzenesulfonyl Chloride is used in the preparation of N-Nosyl-α-amino acid for peptide synthesis.

Production Methods

4,4'-Dinitrodiphenyldisulfide [100-32-3], produced by reaction of 4-chloronitrobenzene with sodium disulfide, is treated with chlorine in HCl – HNO3 by a process similar to that used for 2-nitrobenzenesulfonyl chloride.

Flammability and Explosibility

Not classified

4-Nitrobenzenesulfonyl chloride(98-74-8)Related Product Information

• 4-(Trifluoromethyl)benzene-1-sulfonyl chloride
• Mepiquat chloride
• Sulfuryl chloride
• Choline chloride
• Ammonium chloride
• Calcium chloride
• Benzyl chloride
• 4-ISOPROPYLBENZENESULFONYL CHLORIDE
• Mesitylene-2-sulfonyl chloride
• 2-Nitrobenzenesulfenyl chloride
• Sodium chloride
• N-Acetylsulfanilyl chloride
• Benzenesulfonyl chloride
• 4-Nitrotoluene
• Polyvinyl chloride
• 4-Nitrobenzoic acid
• 4-Chlorobenzenesulfonyl chloride
• 4-Nitrobenzonitrile