ETC-1002
ETC-1002 Basic information
- Product Name:
- ETC-1002
- Synonyms:
-
- ETC-1002
- Bempedoic Acid
- ETC-1002 (ESP 55016)
- ESP 55016
- ETC-1002(BEMPEDOIC ACID)
- CS-1544
- Bempedoic Acid(ETC-1002
- Bempedoate
- CAS:
- 738606-46-7
- MF:
- C19H36O5
- MW:
- 344.49
- Product Categories:
-
- API
- Mol File:
- 738606-46-7.mol
ETC-1002 Chemical Properties
- Melting point:
- 87 - 92°C
- Boiling point:
- 506.5±35.0 °C(Predicted)
- Density
- 1.045±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.55±0.45(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
- InChIKey
- HYHMLYSLQUKXKP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
ETC-1002 Usage And Synthesis
Description
Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.
Description
ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.
Uses
ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
Definition
ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.
ETC-1002Supplier
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