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Voxelotor

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Voxelotor Basic information

Product Name:
Voxelotor
Synonyms:
  • 2-hydroxy-6-([2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl]methoxy)benzaldehyde
  • GBT 440
  • 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde
  • Hemoglobin Modulators-1
  • 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
  • Voxelotor(GBT440, GTX011)
  • Voxelotor
  • Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011
CAS:
1446321-46-5
MF:
C19H19N3O3
MW:
337.37
Product Categories:
  • API
Mol File:
1446321-46-5.mol
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Voxelotor Chemical Properties

Melting point:
95 - 97oC
Boiling point:
539.2±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
7.67±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Voxelotor Usage And Synthesis

Uses

GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.

VoxelotorSupplier

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