Ixazomib Impurity 1 Chemical Properties

Boiling point:

602.0±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Dichloromethane; Chloroform; Methanol; Ethyl Acetate; DMSO;

form 

Solid

pka

12.10±0.46(Predicted)

color 

White

InChIKey

CGUIBVMGUKXODV-OPKBTAHXSA-N

SMILES

C(NCC(N[C@H](B1O[C@@]2(C)[C@@]3([H])C[C@@]([H])(C[C@@]2([H])O1)C3(C)C)CC(C)C)=O)(=O)C1=CC(Cl)=CC=C1Cl

Ixazomib Impurity 1 Usage And Synthesis

Uses

2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide is an intermediate used in the synthesis of Ixazomib (I942000), which is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.

Ixazomib Impurity 1(1201903-02-7)Related Product Information

• Ixazomib citrate
• MLN9708
• (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
• Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-
• 2,3,5-Trichlorobenzoic acid
• 2,3,4,5-Tetrachlorobenzoic acid
• Ixazomib Impurity 72
• 2,3,4-TRICHLOROBENZOIC ACID
• N,N',N"-[boroxin-2,4,6-triyltris[[(1R)-3-methylbutane-1,1-diyl]imino(2-oxoethane-2,1-diyl)] ]tris(2,5-dichlorobenzamide)
• GLYCYLGLYCINE METHYL ESTER HYDROCHLORIDE
• Ixazomib Impurity 49
• Ixazomib Impurity 43
• (R,E)-2-methyl-N-(3-methylbutylidene)propane-2-sulfinamide
• 2,4,5-Trichlorobenzoic acid