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Ixazomib Impurity 1

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Ixazomib Impurity 1 Basic information

Product Name:
Ixazomib Impurity 1
Synonyms:
  • Ixazomib Impurity 1
  • 2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide
  • 2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide
  • Benzamide, 2,5-dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-
  • Ixazomib Impurity N1
  • Ixazomib Impurity R
  • 2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide/ Ixazomib Impurity 1
  • 2,5-Dichloro-N-[2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]dec-4-yl]butyl}amino)-2-oxoethyl]benzamide
CAS:
1201903-02-7
MF:
C24H33BCl2N2O4
MW:
495.25
Mol File:
1201903-02-7.mol
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Ixazomib Impurity 1 Chemical Properties

Boiling point:
602.0±55.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Dichloromethane; Chloroform; Methanol; Ethyl Acetate; DMSO;
form 
Solid
pka
12.10±0.46(Predicted)
color 
White
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Ixazomib Impurity 1 Usage And Synthesis

Uses

2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide is an intermediate used in the synthesis of Ixazomib (I942000), which is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.

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