Amino-PEG11-Amine Chemical Properties

Boiling point:

591.2±45.0 °C(Predicted)

Density 

1.084±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

9.04±0.10(Predicted)

form 

Oil

color 

White to off-white

Amino-PEG11-Amine Usage And Synthesis

Description

Amino-PEG11-Amine is a PEG reagents compring two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

IC 50

PEGs

References

[1] Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15. DOI:10.1021/cb3006243

Amino-PEG11-Amine(479200-82-3)Related Product Information

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• SA-MPEG
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• O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
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• O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL
• 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester
• 1,14-diamino-3,6,9,12-tetraoxatetradecane
• O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)
• 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester
• H2N-PEG13-CH2CH2NH2
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• 3,6,9,12,15,21,24,27,30-Decaoxadotriacontane-1,32-diaMine
• H2N-PEG12-CH2CH2NH2
• 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE
• 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diamine
• 3,6,9-trioxaundecamethylenediamine