Aminoxy-PEG3-Propargyl Chemical Properties

Boiling point:

309.6±32.0 °C(Predicted)

Density 

1.069±0.06 g/cm3(Predicted)

pka

4.21±0.70(Predicted)

form 

Liquid

color 

Colorless to light yellow

Aminoxy-PEG3-Propargyl Usage And Synthesis

Description

Aminooxy-PEG3-propargyl has a alkyne group and an aminooxy group. The aminooxy group reacts with aldehydes or ketones to form a stable oxime linkages. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry reactions. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO2018204416A1.

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