Fluorescein-PEG2-Azide Chemical Properties

solubility 

Soluble in DMSO, DMF, DCM

Fluorescein-PEG2-Azide Usage And Synthesis

Description

Fluorescein-PEG2-azide is a green emitting fluorescent dye derivitative with excitation/emmission maximum 494/517 nm containing an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding.

Uses

Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Fluorescein-thiourea-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Fluorescein-PEG2-Azide(1146195-72-3)Related Product Information

• CI 45350
• FLUORESCEIN MALEIMIDE
• 5(6)-(BIOTINAMIDOCAPROYLAMIDO) PENTYLTHI
• Flurescein-NHS ester
• Fluorescein-PEG3-(N-Boc)-Amine
• 3H-IndoliuM, 2-[5-[1-[6-[(3-azidopropyl)aMino]-6-oxohexyl]-1,3-dihydro-3,3-diMethyl-5-sulfo-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-triMethyl-5-sulfo-, inner salt
• Pyrene -PEG3-azide
• DNP-PEG3-azide
• Azidoacetic acid NHS ester
• Methylamino-PEG3-azide
• BDP FL azide
• diSulfo-Cy5 azide
• Fluorescein-PEG4-azide
• Lipoamido-PEG3-Azide
• FAM azide, 6-isomer
• Fluorescein-PEG6-NHS ester
• Fluorescein-PEG3-N3