Mal-PEG3-NHS ester Chemical Properties

Boiling point:

552.4±60.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

-20°C, protect from light, stored under nitrogen

solubility 

Soluble in DCM

pka

-2.34±0.20(Predicted)

form 

Liquid

color 

Colorless to light yellow

Mal-PEG3-NHS ester Usage And Synthesis

Description

Mal-PEG3-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-PEG3-NHS ester is a noncleavable ADC linker containing a Maleimide group. Mal-PEG3-NHS ester is used for making antibody-drug conjugate[1].

IC 50

Non-cleavable Linker

References

[1] Gautam S, et al. Immobilization of hydrophobic peptidic ligands to hydrophilic chromatographic matrix: a preconcentration approach. Anal Biochem. 2012 Apr 15;423(2):202-9. DOI:10.1016/j.ab.2012.01.020

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