(Z)-Guggulsterone Chemical Properties

Boiling point:

463.3±45.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 5 mg/mL

form 

powder

color 

light yellow

CAS DataBase Reference

95975-55-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37

Safety Statements 

36

WGK Germany 

3

HS Code 

29147000

MSDS

• Language:English Provider:SigmaAldrich

(Z)-Guggulsterone Usage And Synthesis

Uses

Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.

Definition

ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.

Biological Activity

Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).

(Z)-Guggulsterone(95975-55-6)Related Product Information

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