(Z)-Guggulsterone
(Z)-Guggulsterone Basic information
- Product Name:
- (Z)-Guggulsterone
- Synonyms:
-
- 4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE
- PREGNA-4,17(20)-DIENE-3,16-DIONE
- (8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
- pregna-4,17-diene-3,16-dione
- GUGGULISTERONES 95%
- CIS-4,17(20)-PREGNADIENE-3,16-DIONE
- CIS GUGGULSTERONE
- GUGULSTERONE
- CAS:
- 95975-55-6
- MF:
- C21H28O2
- MW:
- 312.45
- EINECS:
- 1308068-626-2
- Product Categories:
-
- Miscellaneous
- Mol File:
- 95975-55-6.mol
(Z)-Guggulsterone Chemical Properties
- Boiling point:
- 463.3±45.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 5 mg/mL
- form
- powder
- color
- light yellow
- CAS DataBase Reference
- 95975-55-6(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
(Z)-Guggulsterone Usage And Synthesis
Uses
Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.
Definition
ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.
Biological Activity
Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).
in vivo
Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2].
| Animal Model: | Wild-type mice with TNBS-induced colitis[2] |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
| Result: | Improved the survival rates of wild-type mice with TNBS-induced colitis. |
IC 50
JNK; Caspase
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(Z)-Guggulsterone(95975-55-6)Related Product Information
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- Tris(2,4-pentanedionato)chroMiuM(III)
- COBALT(II) ACETYLACETONATE
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
- Ferric acetylacetonate
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
- METHYL ISOCYANOACETATE
- Aluminum acetylacetonate
- 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
- Cupric acetylacetonate
- PHENYLSELENOL
- Benzyl isocyanide