Scopolamine Hydrobromide Trihydrate Chemical Properties

Melting point:

197-194 °C

refractive index 

-25.5 ° (C=5, H2O)

storage temp. 

Poison room

solubility 

H2O: soluble50mg/mL

form 

Crystals or Crystalline Powder

color 

white to off-white

optical activity

[α]25/D 24 to 26°, c = 5 in H2O(lit.)

Water Solubility 

H2O: 50mg/mL

Merck 

14,8406

BRN 

6100669

Stability:

Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.

LogP

0.760 (est)

CAS DataBase Reference

6533-68-2(CAS DataBase Reference)

EPA Substance Registry System

Scopolamine hydrobromide trihydrate (6533-68-2)

Safety Information

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

45-25-1

RIDADR 

UN1544 6.1/PG 3

WGK Germany 

1

RTECS 

YM4550000

HazardClass 

6.1

PackingGroup 

III

HS Code 

29399990

MSDS

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Scopolamine Hydrobromide Trihydrate Usage And Synthesis

Description

Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.

Chemical Properties

white crystalline solid

Uses

Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.

Definition

ChEBI: Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85.

Air & Water Reactions

Is sensitive to air, light and moisture. Slightly efflorescent in dry air.

Reactivity Profile

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible.

Mode of action

Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al.

References

[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7.

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