Todralazine hydrochloride
Todralazine hydrochloride Basic information
- Product Name:
- Todralazine hydrochloride
- Synonyms:
-
- apirachol
- binazin
- binazine
- carbazicacid,3-(1-phthalazinyl)-,ethylester,monohydrochloride
- hydrazinecarboxylicacid,2-(1-phthalazinyl)-,ethylester,monohydrochloride
- TODRALAZINE HYDROCHLORIDE
- 2-(1-PHTHALAZINYL)-HYDRAZINECARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
- ethyl 3-(phthalazin-1-yl)carbazate hydrochloride
- CAS:
- 3778-76-5
- MF:
- C11H13ClN4O2
- MW:
- 268.7
- Mol File:
- 3778-76-5.mol
Todralazine hydrochloride Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): slightly
- form
- A crystalline solid
MSDS
- Language:English Provider:SigmaAldrich
Todralazine hydrochloride Usage And Synthesis
Originator
Prorazin,Teisan
Uses
Todralazine Hydrochloride is an antihypertensive agent for research use. Vasodilator.
Uses
Antihypertensor
Manufacturing Process
A suspension of 13 g of hydrazinophthalazine in 500 ml of anhydrous ethanol
is cooled, under agitation to a temperature of -10°C. To the suspension is
added dropwise within 30 min a solution of 4.5 g of ethyl chlorocarbonate in
150 ml of anhydrous ethanol and the reaction mass is agitated for about 2
hours, maintaining a temperature of -10°C. The temperature is then raised to
about 20°C and stirring is continued for 2 hours, whereupon heating is applied
and boiling is maintained for 15 min. After cooling, the separated 1-
hydrazinophthalazine hydrochloride is filtered and washed with anhydrous
ethanol.
The filtrate is evaporated to a dry state under decreased pressure at a
temperature of below 50°C. The residue in a quantity of 8.5 g is dissolved in a
boiling solution of 3 ml of concentrated hydrochloric acid in 15 ml of water,
and after adding 5 ml of 90%-ethanol the solution is cooled to a temperature
of below 0°C.
The separated 1-carboethoxyhydrazinophthalazine hydrochloride is filtered and
washed with anhydrous ethanol. 11.5 g of a raw product are obtained which
for the purpose of purification are dissolved in 15 ml of boiling water with an
addition of 10 ml of 96%-ethanol and after cooling to below 0°C, the pure 1-
carboethoxyhydrazinophthalazine hydrochloride is filtered. 9.8 g of the are
obtained.
Therapeutic Function
Antihypertensive
Todralazine hydrochlorideSupplier
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