Vadadustat Chemical Properties

Melting point:

172-174°C

Boiling point:

674.6±55.0 °C(Predicted)

Density 

1.461±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

4.09±0.40(Predicted)

color 

Pale Beige to Light Beige

Stability:

Hygroscopic

Vadadustat Usage And Synthesis

Description

Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC₅₀s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.

Uses

Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.