Vadadustat
Vadadustat Basic information
- Product Name:
- Vadadustat
- Synonyms:
-
- AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; VADADUSTAT
- PG-1016548;AKB-6548
- Vadadustat
- Vadadustat(AKB-6548/PG-1016548)
- Vadadustat (AKB-6548)
- AKB-6548
- PG 1016548
- PG1016548
- CAS:
- 1000025-07-9
- MF:
- C14H11ClN2O4
- MW:
- 306.7
- Product Categories:
-
- API
- Mol File:
- 1000025-07-9.mol
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Vadadustat Chemical Properties
- Melting point:
- 172-174°C
- Boiling point:
- 674.6±55.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.09±0.40(Predicted)
- color
- Pale Beige to Light Beige
- Stability:
- Hygroscopic
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Vadadustat Usage And Synthesis
Description
Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.
Uses
Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.
VadadustatSupplier
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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MedChemexpress LLC
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