SH5-07
SH5-07 Basic information
- Product Name:
- SH5-07
- Synonyms:
-
- SH5-07
- SH5-07 (SH-5-07)
- Benzamide, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-
- Inhibitor,SH5-07,SH5 07,inhibit,STAT,SH507,SH-5-07
- 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-N-hydroxybenzamide
- SH5-07, 10 mM in DMSO
- CAS:
- 1456632-41-9
- MF:
- C29H28F5N3O5S
- MW:
- 625.61
- Mol File:
- 1456632-41-9.mol
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SH5-07 Chemical Properties
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 50 mg/mL (79.92 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 9.03±0.10(Predicted)
- color
- White to off-white
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SH5-07 Usage And Synthesis
Uses
SH5-?07 is a STAT3-inhibitor blocking the activation of signal transduction and subsequent activation of transcription 3 in chronic myeloid leukemia cell lines.
in vivo
Tail vein injection or oral gavage delivery of SH5-07 or SH4-54 inhibits growth of 90-150 mm3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased c-Myc, Mcl-1 and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed[1].
IC 50
STAT3: 3.9 μM (IC50)
SH5-07Supplier
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Shanghai Rechem science Co., Ltd.
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- 021-31433387 15618786686
- sales@rechemscience.com