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Dolutegravir Impurity 7

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Dolutegravir Impurity 7 Basic information

Product Name:
Dolutegravir Impurity 7
Synonyms:
  • Dolutegravir Impurity 7
  • 2,4-Di-Desfluoro Dolutegravir Sodium salt
  • 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, 3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-N-(phenylmethyl)-, (4R,12aS)-
  • Unii-QC6U8H2E29
  • (4R,12aS)-N-Benzyl-7-hydroxy-4-methyl-6,8-dioxo- 3,4,6,8,12,12a-hexahydro-2H- pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • Durutevir impurity 11
CAS:
2244161-71-3
MF:
C20H21N3O5
MW:
383.4
Mol File:
2244161-71-3.mol
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Dolutegravir Impurity 7 Chemical Properties

Boiling point:
672.0±55.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
pka
4.50±1.00(Predicted)
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Dolutegravir Impurity 7 Usage And Synthesis

Uses

Desdifluoro Dolutegravir is impurity B of Dolutegravir(D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

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