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Pirarubicin

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Pirarubicin Basic information

Product Name:
Pirarubicin
Synonyms:
  • THP-ADM
  • THEPRUBICIN
  • (8s-cis)-droxyacetyl)-1-methoxy
  • (8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  • Tepirubicin
  • Therarubiein
  • THP-adriamycin
  • (8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
CAS:
72496-41-4
MF:
C32H37NO12
MW:
627.64
Product Categories:
  • Inhibitors
  • API
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
72496-41-4.mol
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Pirarubicin Chemical Properties

Melting point:
188-192°C (dec.)
alpha 
D25 +175 ±25° (c = 0.2 in CHCl3)
Boiling point:
834.7±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
ethanol: soluble25mg/mL
form 
powder
pka
7.35±0.60(Predicted)
color 
Orange to Red
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
QI9296000
Toxicity
LD50 i.v. in mice: 27.8 mg/kg (Umezawa, 1979)

MSDS

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Pirarubicin Usage And Synthesis

Description

Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.

Chemical Properties

Red Solid

Originator

Meiji Seika (Japan)

Uses

Structural analog of Doxorubicin. Antineoplastic.

Definition

ChEBI: (7S,9S)-7-[[(2R,4S,5S,6S)-4-amino-6-methyl-5-[[(2R)-2-oxanyl]oxy]-2-oxanyl]oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione is an anthracycline.

brand name

Pinorubicin; Therarubucin

Pirarubicin Preparation Products And Raw materials

Raw materials

Silica gelTetrahydropyranDoxorubicin hydrochlorideAdriamycin

PirarubicinSupplier

Shanghai Mokai Pharmaceutical Technology Co., Ltd. Gold
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021-60951261 18601606476
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nancy@mkpharma.cn
Jiangxi ravel Biotechnology Co.,Ltd Gold
Tel
18502762009
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721846333@qq.com
Hubei wei shi reagent group ltd., company Gold
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027-59102966 18717199209
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2853877583@qq.com
Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
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