SGC2085 Chemical Properties

Boiling point:

498.3±45.0 °C(Predicted)

Density 

1.097±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO : ≥ 32 mg/mL (102.43 mM)

pka

14.83±0.46(Predicted)

form 

Solid

color 

White to off-white

InChI

InChI=1S/C19H24N2O2/c1-12-7-13(2)9-17(8-12)23-18-6-5-16(10-14(18)3)11-21-19(22)15(4)20/h5-10,15H,11,20H2,1-4H3,(H,21,22)/t15-/m0/s1

InChIKey

GLFOFXKMALJTCZ-HNNXBMFYSA-N

SMILES

C(NCC1=CC=C(OC2=CC(C)=CC(C)=C2)C(C)=C1)(=O)[C@@H](N)C

SGC2085 Usage And Synthesis

Uses

SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins[1].

IC 50

PRMT4

References

[1] Ferreira de Freitas R, et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem. 2016 Jul 28;59(14):6838-47. DOI:10.1021/acs.jmedchem.6b00668

SGC2085(1821908-48-8)Related Product Information

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