Acid-PEG4-mono-methyl ester Chemical Properties

Boiling point:

433.8±40.0 °C(Predicted)

Density 

1.156±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Light yellow to yellow

Acid-PEG4-mono-methyl ester Usage And Synthesis

Description

Acid-PEG4-mono-methyl ester is a PEG linker with a carboxylic acid and methyl ester group. Methyl ester can be hydrolyzed under strong basic condition. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Kanazaki K, et al. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. DOI:10.1016/j.jconrel.2016.02.017

Acid-PEG4-mono-methyl ester(2028284-75-3)Related Product Information

• Acid-PEG1-t-butyl ester
• Bis-PEG12-acid
• S-acetyl-PEG3-acid
• Acid-PEG12-NHS ester
• Acid-PEG10-NHS ester
• Acid-PEG5-NHS ester
• Acid-PEG25-NHS ester
• Acid-PEG5-mono-methyl ester
• Acid-PEG6-mono-methyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG9-NHS ester
• Acid-PEG13-NHS ester
• Acid-PEG4-t-butyl ester
• Acid-PEG4-Sulfone-PEG4-Acid
• Acid-PEG4-S-PEG4-Acid