Aminooxy-PEG4-Propargyl Chemical Properties

Boiling point:

353.6±37.0 °C(Predicted)

Density 

1.078±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, sealed storage, away from moisture and light

form 

Liquid

pka

4.21±0.70(Predicted)

color 

Colorless to light yellow

Aminooxy-PEG4-Propargyl Usage And Synthesis

Description

Aminooxy-PEG4-propargyl is a aldehyde reactive crosslinker. The aminooxy group reacts with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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