Boc-Aminooxy-PEG2-amine CAS#: 252378-69-1

Boc-Aminooxy-PEG2-amine Basic information

Product Name:

Boc-Aminooxy-PEG2-amine

Synonyms:

Boc-Aminooxy-PEG2-amine
t-Boc-Aminooxy-PEG2-amine
BOC-Aminooxy -PEG2-Amino
Boc-Aminooxy-PEG2-C2-amine
3,6,9-Trioxa-2-azaundecanoic acid, 11-amino-, 1,1-dimethylethyl ester
2-[2-[2-[(Boc-amino)oxy]ethoxy]ethoxy]ethanamine
t-Boc-Aminooxy-PEG2-amine boc
BocHNO-PEG2-CH2CH2NH2

CAS:

252378-69-1

MF:

C11H24N2O5

MW:

264.32

Mol File:

252378-69-1.mol

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Boc-Aminooxy-PEG2-amine Chemical Properties

Density: 1.077±0.06 g/cm3(Predicted)
storage temp.: -20°C, stored under nitrogen
solubility: Soluble in Water, DMSO, DMF, DCM
pka: 8.74±0.10(Predicted)
form: Viscous Liquid
color: Colorless to light yellow

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Boc-Aminooxy-PEG2-amine Usage And Synthesis

Description

t-Boc-Aminooxy-PEG2-amine contains a Boc-protected aminooxy group and a free amino(NH2) group. Amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc- aminooxy can be deprotected under mild acidic conditions and then reacts with an aldehyde to form a linkage.

Uses

Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Boc-Aminooxy-PEG2-amineSupplier

Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd Gold

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Email: sales@ypptech.com.cn

Borenpharm Co., Ltd

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Jinan elephant international trading co., LTD

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Amatek Scientific Co. Ltd.

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SHANGHAI FDC-CHEMICAL CO.,LTD

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Email: sales@fdc-chemical.com

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