Biotin-PEG₄-Azide Chemical Properties

Melting point:

102.0 to 106.0 °C

storage temp. 

-20°C, sealed storage, away from moisture

form 

powder to lump

color 

White to Light yellow

InChIKey

PVEHVEYAPUNCCP-LLFBLNAENA-N

SMILES

C(NCCOCCOCCOCCOCCN=[N+]=[N-])(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1 |&1:24,25,31,r|

Safety Information

HS Code 

2934.99.9001

Biotin-PEG₄-Azide Usage And Synthesis

Description

Biotin-PEG4-azide is a very useful biotinylation reagent that enable Click Chemistry reaction with alkyne, such as Propargyl, DBCO or BCN reagent to form a stable bond. PEG4 spacer increases aqueous solubility of the molecules conjugated to the biotin. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Uses

Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

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