Diethyl phosphite Chemical Properties

Melting point:

-70 °C

Boiling point:

50-51 °C/2 mmHg (lit.)

Density 

1.072 g/mL at 25 °C (lit.)

vapor pressure 

7hPa at 20℃

refractive index 

n20/D 1.407(lit.)

Flash point:

180 °F

form 

Liquid

color 

Colorless

Specific Gravity

1.072

Water Solubility 

miscible (hydrolysis)

Sensitive 

Moisture Sensitive

Hydrolytic Sensitivity

7: reacts slowly with moisture/water

BRN 

605759

Stability:

Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible.

InChIKey

MJUJXFBTEFXVKU-UHFFFAOYSA-N

LogP

-0.15

CAS DataBase Reference

762-04-9(CAS DataBase Reference)

NIST Chemistry Reference

Phosphonic acid, diethyl ester(762-04-9)

EPA Substance Registry System

Diethyl phosphite (762-04-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36/37/39-37/39-28-27

WGK Germany 

1

RTECS 

TG7875000

F 

10-13-21

TSCA 

Yes

HS Code 

29209014

Hazardous Substances Data

762-04-9(Hazardous Substances Data)

MSDS

• Language:English Provider:Diethyl hydrogen phosphonate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Diethyl phosphite Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Diethyl phosphite is precursor used for the synthesis of various organophosphorus compounds. used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.

Uses

Diethyl phosphite (DEPI) is a versatile reactive intermediate used in the production of various phosphorus based substances. It may be used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.
It may be used:

1. in the stereoselective synthesis of β-fluorinated alkylphosphonates
2. Used in synthesis of homoallylic bromide
3. Used in synthesis of series of carbazole-based α-aminophosphonates
4. used as an extraction agent and phosphate intermediate.
5. Used in synthesis of pesticides kitazine and phosethyl-Al as well as synthetic O, O-diethyl phosphoryl chloride.
6. used for the synthesis of plasticizers, flame retardants, etc.
7. Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Definition

ChEBI: A phosphonic ester that is the diethyl ester of phosphonic acid.

Synthesis Reference(s)

Synthetic Communications, 18, p. 665, 1988 DOI: 10.1080/00397918808077352

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 3327, 1988 DOI: 10.1016/0040-4039(88)85153-0

General Description

Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.

Diethyl phosphite(762-04-9)Related Product Information

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