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ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Heterocyclic compound >  Thiophene compounds >  2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE

Basic information Safety Supplier Related

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Basic information

Product Name:
2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE
Synonyms:
  • 2-amino-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • 2-azanyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
  • 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide(SALTDATA: FREE)
  • Benzo[b]thiophene-3-carboxaMide, 2-aMino-4,5,6,7-tetrahydro-
  • 2-Amino-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxamide
  • TIMTEC-BB SBB000354
  • 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE
  • AKOS MSC-0467
CAS:
4815-28-5
MF:
C9H12N2OS
MW:
196.27
Product Categories:
  • Sulphur Derivatives
Mol File:
4815-28-5.mol
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2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Chemical Properties

Melting point:
195-197℃
Boiling point:
332.5±42.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
15.70±0.20(Predicted)
CAS DataBase Reference
4815-28-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
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2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE Usage And Synthesis

Hazard

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Synthesis

The synthesis of 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE is as follows:
A solution of aminothiophene EO (prepared as described in Example C; 500mg, 2.8 mmol) in concentrated sulphuric acid (5ml) was stirred at room temperature for 65 hours. The reaction mixture was poured cautiously into ice-cold aqueous potassium carbonate, diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water and brine, dried over magnesium sulphate and evaporated to dryness under reduced pressure to give the desired product (383mg, 70%) as an off-white solid. 

2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESupplier

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