NIFEDIPINE-D6 Chemical Properties

Melting point:

164-165°C

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated)

form 

Solid

color 

Yellow

NIFEDIPINE-D6 Usage And Synthesis

Description

Nifedipine-d₆ is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina.

Chemical Properties

Yellow Solid

Uses

Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker.

Uses

(Nifedipine-d6) Labeled Nifedipine, intended for use as an internal standard for the quantification of Nifedipine by GC- or LC-mass spectrometry.

NIFEDIPINE-D6(1188266-14-9)Related Product Information

• Nifedipine
• Vancomycin hydrochloride
• Nifedipine Pyrimidine Impurity
• nifedipine iMpurity C
• BROMOSULBACTAM
• sodium [2S-(2alpha,5alpha,6beta)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• SulbactaM M-1
• 2,6-Ntp
• Nifedipine Impurity 9
• methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• (S)-(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Monomethyl Ester
• (3S)-6,6-DIBROMO-2,2-DIMETHYLPENAM-3-CARBOXYLIC ACID 1,1-DIOXIDE
• Nifedipine Impurity 21
• Methyl 3-aminocrotonate
• METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE
• (E)-methyl 3-aminobut-2-enoate
• Sulbactam sodium
• 6,6-DIBROMOPENICILLANIC ACID