Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Organic Chemistry >  Inorganic acid Esters >  DIETHYL PHOSPHATE

DIETHYL PHOSPHATE

Basic information Safety Supplier Related

DIETHYL PHOSPHATE Basic information

Product Name:
DIETHYL PHOSPHATE
Synonyms:
  • diethylacidphosphate
  • di-ethylphosphat
  • diethylphosphoricacid
  • Ethyl phosphate, (ETO)2(HO)PO
  • o,o-diethylhydrogenphosphate
  • Phosphoricacid,diethylester
  • DIETHYL PHOSPHATE
  • DIETHYL HYDROGEN PHOSPHATE
CAS:
598-02-7
MF:
C4H11O4P
MW:
154.1
EINECS:
209-912-5
Product Categories:
  • Alphabetic
  • D
  • DID - DINEnvironmental Standards
  • Metabolites
  • Pesticides&Metabolites
Mol File:
598-02-7.mol
More
Less

DIETHYL PHOSPHATE Chemical Properties

Melting point:
6 °C
Boiling point:
203 °C
Density 
1.29
refractive index 
1.4170
Flash point:
91 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
1.42±0.50(Predicted)
form 
Liquid
color 
Clear colorless to light yellow-orange
Stability:
Moisture Sensitive
InChI
InChI=1S/C4H11O4P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3,(H,5,6)
InChIKey
UCQFCFPECQILOL-UHFFFAOYSA-N
SMILES
P(O)(OCC)(OCC)=O
EPA Substance Registry System
Phosphoric acid, diethyl ester (598-02-7)
More
Less

Safety Information

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
37/39-26-36-45-36/37-16-7
RTECS 
TC0665000
HS Code 
29199000

MSDS

  • Language:English Provider:ACROS
More
Less

DIETHYL PHOSPHATE Usage And Synthesis

Chemical Properties

clear colorless to light yellow-orange liquid

Uses

Phosphoric acid diethyl ester is an organophosphate that is usually found in pesticides and is known to induce changes in male hormone profile by decreasing serum testosterone and inhibin B levels. Phosphoric acid diethyl ester is also known to negatively affect the health of women and newborns living in agricultural communities.

Definition

ChEBI: A dialkyl phosphate having ethyl as the alkyl group.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 2089, 1963 DOI: 10.1021/jo01043a035
Tetrahedron Letters, 29, p. 619, 1988 DOI: 10.1016/S0040-4039(00)80165-3

in vivo

Diethyl phosphate (oral gavage; 0.08-0.8 mg/kg; 24 weeks) can lead to the disturbance of endocrine hormones and related metabolic indexes in rats[1].
Diethyl phosphate (oral gavage; 0.08-0.13 mg/kg; 20 weeks) affects the intestinal microbiota, serum hormones and pro-inflammatory cytokines[2].

Animal Model:Adult male Wistar rats aged 7-8 weeks old (344.4 ± 21.0 g)[1]
Dosage:0.08 or 0.8 mg/kg
Administration:Oral gavage (i.g.); 24 weeks
Result:Did not affect the body weight of rats and food intake.
Significantly decreased serum levels of TC, TG and LDL-C in rats.
Resulted in a decrease in sperm concentration, while the sperm abnormality rate increased, did not affect the sperm morphology in rats.
Increased the serum levels of FSH and estradiol, while the serum levels of LH and testosterone decreased.
Could cause thyroid-related hormone disorders in the serum of rats, causing symptoms of hyperthyroidism in rats, and could also lead to abnormal expression of thyroid hormone-related genes in the rat liver.
Animal Model:Male Wistar rats aged 7 weeks old[2]
Dosage:0.08 or 0.13 mg/kg
Administration:Oral gavage (i.g.); 20 weeks
Result:Significantly enriched opportunistic pathogens, including Paraprevotella, Parabacteroides, Alloprevotella, and Helicobacter, leading to a decrease in IL-6.
Enriched the butyrate-producing genera, Alloprevotella and Intestinimonas, leading to an increase in estradiol and a resulting decrease in total triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C) in high dose group.
Induced increases in peptide tyrosine-tyrosine (PYY) and ghrelin.

DIETHYL PHOSPHATE Preparation Products And Raw materials

Preparation Products

Diethyl cyanophosphonate

Raw materials

Diethyl phosphite

DIETHYL PHOSPHATESupplier

Shanghai Brain Biotechnology Co., Ltd. Gold
Tel
13564638271
Email
shhjiang1977@163.com
Nanjing Easichem Co. ltd. Gold
Tel
18061688856
Email
easichem@126.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Email
sales.bj@hwrkchemical.com
More
Less

DIETHYL PHOSPHATE(598-02-7)Related Product Information