Ginsenoside Rg1 Chemical Properties

Melting point:

194～197℃

Boiling point:

898.5±65.0 °C(Predicted)

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)

pka

12.91±0.70(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

InChIKey

YURJSTAIMNSZAE-OLCOBRLXNA-N

LogP

1.670 (est)

CAS DataBase Reference

22427-39-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

22-39/23/24/25-23/24/25-11

Safety Statements 

2-45-36/37-16-7-24/25

WGK Germany 

3

RTECS 

LY9537200

HS Code 

29389090

Ginsenoside Rg1 Usage And Synthesis

Description

Ginsenoside RG1(Rg1) is a natural product found in Panax notoginseng, Panax ginseng, and Panax vietnamensis. It is one of the primary bioactive ingredients in Panax notoginseng saponins. Numerous studies have indicated that Rg1 plays significant roles in health benefits such as anticancer, neuroprotective, anti-senescence, anti-inflammation, and antioxidative effects. Also, extensive research has demonstrated that Rg1 is associated with various diseases, including cardiovascular disease, Alzheimer’s disease, spinal cord injury, and liver injury. Xue et al. and Yu et al. demonstrated that Rg1 ameliorated streptozotocin-induced oxidative stress and myocardial apoptosis and suppressed HG-induced mesenchymal activation and fibrosis[1].

Chemical Properties

White solid

Uses

Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.

Definition

ChEBI: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 <ital pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 posit on.

References

[1] Hui Liu. “Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway.” Annals of translational medicine 9 24 (2021): 1789.

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