Tubulysin B
Tubulysin B Basic information
- Product Name:
- Tubulysin B
- Synonyms:
-
- Tubulysin B
- Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-N-[(butanoyloxy)methyl]-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}pentanamido]-4-methylpentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid
- CAS:
- 205304-87-6
- MF:
- C42H63N5O10S
- MW:
- 830.05
- Mol File:
- 205304-87-6.mol
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Tubulysin B Chemical Properties
- Boiling point:
- 978.0±65.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.52±0.23(Predicted)
- color
- White to off-white
- InChIKey
- HWCIETDQUHYHGQ-OSGLCLOFNA-N
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Tubulysin B Usage And Synthesis
Description
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
Definition
ChEBI: Tubulysin B is a butyrate ester.
in vitro
Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.
Tubulysin BSupplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Angel Pharmatech, Ltd.
- Tel
- 17317130613
- 3358272972@qq.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
- Tel
- 0571-85361029
- synstar518@163.com
BOC Sciences
- Tel
- 16314854226; +16314854226
- inquiry@bocsci.com