Tubulysin B Chemical Properties

Boiling point:

978.0±65.0 °C(Predicted)

Density 

1.204±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

Solid

pka

4.52±0.23(Predicted)

color 

White to off-white

InChIKey

HWCIETDQUHYHGQ-OSGLCLOFNA-N

Tubulysin B Usage And Synthesis

Description

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agent isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug-resistant properties. It is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.

Uses

Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties[1].Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].

Definition

ChEBI: Tubulysin B is a butyrate ester.

in vitro

Tubulysin B has IC50s of 0.6 and 0.9 nM against KB and A549 tumors cell lines, respectively.

References

[1] Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. DOI:10.1021/acs.bioconjchem.9b00335
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041