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CIS-ENTACAPONE

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CIS-ENTACAPONE Basic information

Product Name:
CIS-ENTACAPONE
Synonyms:
  • (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
  • (Z)-Entacapone
  • CIS-ENTACAPONE
  • Entacapone impurity A -I
  • (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • Entacapone Impurity 17(Entacapone EP Impurity A)
  • Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide)
  • Entacapone EP IMpurity A
CAS:
145195-63-7
MF:
C14H15N3O5
MW:
305.29
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
145195-63-7.mol
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CIS-ENTACAPONE Chemical Properties

Melting point:
142-144°C
Boiling point:
526.6±50.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Dichloromethane (Slightly), Methanol (Slightly)
pka
5.15±0.50(Predicted)
color 
Yellow to Orange
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Safety Information

HS Code 
2926900005
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CIS-ENTACAPONE Usage And Synthesis

Description

cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.

Chemical Properties

Orange Solid

Uses

cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.

Definition

ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.

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