CMPD101 CAS#: 865608-11-3

Product Name:

CMPD101

Synonyms:

CMPD101
3-[[[4-Methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzamide
Benzamide, 3-[[[4-methyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]methyl]amino]-N-[[2-(trifluoromethyl)phenyl]methyl]-
Takeda101
Takeda compound 101
Rho-associated kinase,Rho-kinase,ROK,PKC,CMPD 101,desensitization,Inhibitor,inhibit,failure,CMPD101,Neuron,ROCK,Protein kinase C,heart,CMPD-101,Rho-associated protein kinase
3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-{[2-(trifluoromethyl)phenyl]methyl}benzamide
CMPD101, 10 mM in DMSO

CAS:

865608-11-3

MF:

C24H21F3N6O

MW:

466.46

Mol File:

865608-11-3.mol

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Melting point:: >80°C (dec.)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
InChI: InChI=1S/C24H21F3N6O/c1-33-21(31-32-22(33)16-9-11-28-12-10-16)15-29-19-7-4-6-17(13-19)23(34)30-14-18-5-2-3-8-20(18)24(25,26)27/h2-13,29H,14-15H2,1H3,(H,30,34)
InChIKey: WFOVEDJTASPCIR-UHFFFAOYSA-N
SMILES: C(NCC1=CC=CC=C1C(F)(F)F)(=O)C1=CC=CC(NCC2N(C)C(C3C=CN=CC=3)=NN=2)=C1

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CMPD101 is a potent and selective GRK2/3 inhibitor.

GRK2: 18 nM (IC₅₀); GRK3: 5.4 nM (IC₅₀); PKCα: 8.1 μM (IC₅₀); ROCK2: 1.4 μM (IC₅₀)

-20°C

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