4-Fluorophenylacetic acid Chemical Properties

Melting point:

81-83 °C (lit.)

Boiling point:

164°C (2.25 torr)

Density 

1.1850 (estimate)

Flash point:

>100°C

storage temp. 

Sealed in dry,Room Temperature

pka

pK1:4.25 (25°C)

form 

Shiny Crystalline Powder or Flakes

color 

White

Water Solubility 

Insoluble in water.

Merck 

14,4177

BRN 

972145

CAS DataBase Reference

405-50-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetic acid, 4-fluoro-(405-50-5)

EPA Substance Registry System

Benzeneacetic acid, 4-fluoro- (405-50-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

38-36/37/38

Safety Statements 

22-24/25-36/37/39-27-26

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29163900

MSDS

• Language:English Provider:p-Fluorophenylacetic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Fluorophenylacetic acid Usage And Synthesis

Chemical Properties

white shiny crystalline powder or flakes

Uses

4-Fluorophenylacetic acid is used as an intermediate in the production of fluorinated anesthetics.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 6037, 1956 DOI: 10.1021/ja01604a023

Purification Methods

Crystallise it from heptane, but it is best purified by distillation at high vacuum. [Bergmann et al. J Am Chem Soc 78 6037 1956, Beilstein 9 III 2261, 9 IV 1672.]

4-Fluorophenylacetic acid(405-50-5)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• 4-Fluoroanisole
• 4-Bromofluorobenzene
• 4-Fluorophenethylamine
• Folic acid
• Stearic acid
• 4-Fluoroacetophenone
• 4-Fluorobenzoic acid
• Transfluthrin
• Florfenicol
• 4-Fluorobenzaldehyde
• Citric acid
• 4-Fluorothiophenol
• (4-FLUORO-PHENYL)-ACETALDEHYDE
• 4-Fluorophenethyl alcohol
• 4-Fluorobenzyl alcohol
• 4-Fluorophenylacetyl chloride
• Ascoric Acid