5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Chemical Properties

Boiling point:

234℃

Density 

1.266

Flash point:

96℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2-methoxy-5-fluoropyridine-4-carboxaldehyde from (5-fluoro-2-methoxypyridin-4-yl)methanol was as follows: (5-fluoro-2-methoxypyridin-4-yl)methanol (1.40 g, 8.91 mmol) was dissolved in dichloromethane (DCM, 50 mL) with stirring. A dichloromethane (DCM, 70 mL) solution of Dess-Martin periodontane (4.535 g, 10.69 mmol) was slowly added and the reaction mixture continued to be stirred for 1.5 hours at room temperature. After completion of the reaction, the organic layer was washed sequentially with 1 M aqueous sodium hydroxide solution (2 x 75 mL), water (75 mL) and brine, dried over anhydrous magnesium sulfate (MgSO?), filtered and concentrated to afford 2-methoxy-5-fluoropyridine-4-carbaldehyde as a yellow oil (0.481 g, 35% yield).1H NMR (399.902 MHz, CDCl?) δ 3.94 (s, 3H), 7.08-7.11 (m, 1H), 8.20-8.22 (m, 1H), 10.32 (s, 1H).

References

[1] Patent: US2008/4302, 2008, A1. Location in patent: Page/Page column 74

5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE(884495-12-9)Related Product Information

• 2-Methoxypyridine
• 5-FLUORO-2-METHOXYISONICOTINIC ACID
• 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE
• 4-Pyridinecarboxaldehyde, 5-fluoro-1,2-dihydro-2-oxo- (9CI)