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2-Chloropyrazine

Basic information Safety Supplier Related

2-Chloropyrazine Basic information

Product Name:
2-Chloropyrazine
Synonyms:
  • 2 - chloride pyrazine
  • Pyrazine, 2-chloro-
  • 2-Chloropyrazine 97%
  • 2-chloropyrazine(SALTDATA: FREE)
  • 2-Chloropyrazine, 98% 10GR
  • Pyrazin-2-yl chloride
  • Pyrazine, chloro- (6CI,7CI,8CI,9CI)
  • 2-Chloro-1,4-diazine
CAS:
14508-49-7
MF:
C4H3ClN2
MW:
114.53
EINECS:
238-517-0
Product Categories:
  • Inhibitors
  • Pesticides intermediate
  • Chloropyrazines, etc.
  • PyrazinesHeterocyclic Building Blocks
  • API Intermediate
  • alkyl chloride
  • Halides
  • Heterocycles
  • Pyrazines
  • Pyrazine
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • bc0001
Mol File:
14508-49-7.mol
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2-Chloropyrazine Chemical Properties

Melting point:
153~154℃
Boiling point:
153-154 °C (lit.)
Density 
1.283 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.539(lit.)
Flash point:
136 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in Methanol
form 
Liquid
pka
-1.10±0.10(Predicted)
color 
Clear colorless to yellow
Specific Gravity
1.283
Water Solubility 
INSOLUBLE
BRN 
107019
CAS DataBase Reference
14508-49-7(CAS DataBase Reference)
NIST Chemistry Reference
Chloropyrazine(14508-49-7)
EPA Substance Registry System
Pyrazine, chloro- (14508-49-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29339990

MSDS

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2-Chloropyrazine Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid

Uses

2-Chloropyrazine is used in cardiotonic, in biological, drug, flavoring and perfumery industry.

Application

2-Chloropyrazine is used as a reagent in the synthesis of hetaryloxy benzoxaborole compounds which have antimalarial activity. 2-Chloropyrazine is also used to prepare 4,5-disubstituted 6-aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles which are broad-spectrum serine β-lactamase inhibitors.

Purification Methods

Fractionally distil it through a short column packed with glass helices. It has apenetrating, mildly pungent odour with a high vapour pressure at room temperature. [Erickson & Spoerri J Am Chem Soc 68 400 1946, Hetman & O.Donnell J Org Chem 28 1682 1963, Beilstein 23/5 V 366.]

2-ChloropyrazineSupplier

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