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2-Chloropyrazine

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2-Chloropyrazine Basic information

Product Name:
2-Chloropyrazine
Synonyms:
  • 2 - chloride pyrazine
  • Pyrazine, 2-chloro-
  • 2-Chloropyrazine 97%
  • 2-chloropyrazine(SALTDATA: FREE)
  • 2-Chloropyrazine, 98% 10GR
  • Pyrazin-2-yl chloride
  • Pyrazine, chloro- (6CI,7CI,8CI,9CI)
  • 2-Chloro-1,4-diazine
CAS:
14508-49-7
MF:
C4H3ClN2
MW:
114.53
EINECS:
238-517-0
Product Categories:
  • Inhibitors
  • Pesticides intermediate
  • Chloropyrazines, etc.
  • PyrazinesHeterocyclic Building Blocks
  • API Intermediate
  • alkyl chloride
  • Halides
  • Heterocycles
  • Pyrazines
  • Pyrazine
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • bc0001
Mol File:
14508-49-7.mol
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2-Chloropyrazine Chemical Properties

Melting point:
153～154℃
Boiling point:
153-154 °C (lit.)
Density 
1.283 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.539(lit.)
Flash point:
136 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in Methanol
pka
-1.10±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.283
Water Solubility 
INSOLUBLE
BRN 
107019
LogP
0.700
CAS DataBase Reference
14508-49-7(CAS DataBase Reference)
NIST Chemistry Reference
Chloropyrazine(14508-49-7)
EPA Substance Registry System
Pyrazine, chloro- (14508-49-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29339990

MSDS

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2-Chloropyrazine Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid

Uses

2-Chloropyrazine is used in cardiotonic, in biological, drug, flavoring and perfumery industry.

Application

2-Chloropyrazine is used as a reagent in the synthesis of hetaryloxy benzoxaborole compounds which have antimalarial activity. 2-Chloropyrazine is also used to prepare 4,5-disubstituted 6-aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles which are broad-spectrum serine β-lactamase inhibitors.

Definition

ChEBI: 2-chloropyrazine is a member of pyrazines.

Purification Methods

Fractionally distil it through a short column packed with glass helices. It has apenetrating, mildly pungent odour with a high vapour pressure at room temperature. [Erickson & Spoerri J Am Chem Soc 68 400 1946, Hetman & O.Donnell J Org Chem 28 1682 1963, Beilstein 23/5 V 366.]

2-Chloropyrazine Preparation Products And Raw materials

Preparation Products

N-Boc-5,6,7,8-tetrahydro-3-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ,98%METHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE1-(2-PYRAZINYL)-PIPERAZINE3-Chloropyrazine-2-carbonitrile3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride2,3-Dichloropyrazine3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazinePyrazinecarbonitrile2-Methyl-3-(methylthio)pyrazine

Raw materials

Glyoxal

2-ChloropyrazineSupplier

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. Gold
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133-96369453 18678026865
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Shanghai Boyle Chemical Co., Ltd.
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021-50182298 021-50180596
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sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
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2-Chloropyrazine(14508-49-7)Related Product Information