Steviol Chemical Properties

Melting point:

215°

alpha 

D -94.7°

Boiling point:

464.5±45.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: >10mg/mL

form 

powder

pka

4.65±0.60(Predicted)

color 

white to tan

Stability:

Light Sensitive

InChIKey

QFVOYBUQQBFCRH-ZPNQOMQUSA-N

LogP

4.035 (est)

Safety Information

WGK Germany 

3

RTECS 

NZ8176000

HS Code 

29181990

Steviol Usage And Synthesis

Chemical Properties

Pure white crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from stevia.

Uses

Has been proposed as non-nutritive sweetening agent.

Uses

Steviol is an aglycone of the natural sweetener Stevioside (90%, S686730) and is found to be highly mutagenic compared to Stevioside.

Definition

ChEBI: Steviol is an ent-kaurane diterpenoid that is 5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid in which the hydrogen at position 13 has been replaced by a hydroxy group. It has a role as an antineoplastic agent. It is a tetracyclic diterpenoid, a tertiary allylic alcohol, a monocarboxylic acid, a bridged compound and an ent-kaurane diterpenoid. It is a conjugate acid of a steviol(1-).

Health Hazard

Steviol has been reported to be mutagenic.Wide use of stevia in Japan for >30 years did not produce any known deleterious side effects. In Japan, enzymatically glycosylated blend of stevioside and rebaudioside A, which appears to impart a cleaner taste profile, is also available commercially.

Biochem/physiol Actions

Steviol is an inhibitor of hOAT1 and hOAT3 organic anion transporters. Human organic anion transporter hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in the body disposition of clinically important drugs including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories. Steviol is a useful tool for studying renal drug clearance.

Steviol(471-80-7)Related Product Information

• Citric acid
• Folic acid
• Stearic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Ascoric Acid
• RUBUSOSIDE
• Rebaudioside A
• SteviaP.E./Stevioside,SteviaP.E.extract/Stevioside
• Stevioside
• Rebaudioside D
• glucosilsteviol
• STEVIOL METHYL ESTER
• Steviol
• GLUCOSYL STEVIOSIDE
• STEVIOSIDE P. E.
• Stevia/Stevioside
• ZERENEX ZX006899
• 15-oxosteviol