Steviol Chemical Properties

Melting point:

215°

alpha 

D -94.7°

Boiling point:

464.5±45.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: >10mg/mL

form 

powder

pka

4.65±0.60(Predicted)

color 

white to tan

Stability:

Light Sensitive

InChIKey

QFVOYBUQQBFCRH-ZPNQOMQUSA-N

LogP

4.035 (est)

Safety Information

WGK Germany 

3

RTECS 

NZ8176000

HS Code 

29181990

Steviol Usage And Synthesis

Uses

Steviol is an aglycone of the natural sweetener Stevioside (90%, S686730) and is found to be highly mutagenic compared to Stevioside.

Uses

Has been proposed as non-nutritive sweetening agent.

Definition

ChEBI: Steviol is an ent-kaurane diterpenoid that is 5beta,8alpha,9beta,10alpha-kaur-16-en-18-oic acid in which the hydrogen at position 13 has been replaced by a hydroxy group. It has a role as an antineoplastic agent. It is a tetracyclic diterpenoid, a tertiary allylic alcohol, a monocarboxylic acid, a bridged compound and an ent-kaurane diterpenoid. It is a conjugate acid of a steviol(1-).

Health Hazard

Steviol has been reported to be mutagenic.Wide use of stevia in Japan for >30 years did not produce any known deleterious side effects. In Japan, enzymatically glycosylated blend of stevioside and rebaudioside A, which appears to impart a cleaner taste profile, is also available commercially.

Biochem/physiol Actions

Steviol is an inhibitor of hOAT1 and hOAT3 organic anion transporters. Human organic anion transporter hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in the body disposition of clinically important drugs including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories. Steviol is a useful tool for studying renal drug clearance.

Steviol(471-80-7)Related Product Information

• Folic acid
• Citric acid
• Stearic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Ascoric Acid
• RUBUSOSIDE
• Rebaudioside A
• STEVIOSIDE(RG),STEVIOSIDE(P),Stevioside,STEVIOSIDE WITH HPLC
• SteviaP.E./Stevioside,SteviaP.E.extract/Stevioside
• Rebaudioside D
• glucosilsteviol
• STEVIOL METHYL ESTER
• Steviol
• GLUCOSYL STEVIOSIDE
• STEVIOSIDE P. E.
• Stevia/Stevioside
• ZERENEX ZX006899
• 15-oxosteviol