R-(+)-LISURIDE HYDROGEN MALEATE
R-(+)-LISURIDE HYDROGEN MALEATE Basic information
- Product Name:
- R-(+)-LISURIDE HYDROGEN MALEATE
- Synonyms:
-
- 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylureamaleate(1:1)
- 3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-uremaleate(1:1)
- 3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylureahydrogenmaleate
- cuvalit
- lisuridehydrogenmaleate
- lisuridemaleate
- lysenyl
- lysenylbimaleate
- CAS:
- 19875-60-6
- MF:
- C24H30N4O5
- MW:
- 454.52
- EINECS:
- 243-387-3
- Mol File:
- 19875-60-6.mol
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R-(+)-LISURIDE HYDROGEN MALEATE Chemical Properties
- Melting point:
- 200° (dec)
- alpha
- D20 +288° (c = 0.5 in methanol)
- storage temp.
- Desiccate at RT
- solubility
- DMSO:34.83(Max Conc. mg/mL);76.63(Max Conc. mM)
- form
- Solid
- color
- Off-White to Light Yellow
- Stability:
- Hygroscopic
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R-(+)-LISURIDE HYDROGEN MALEATE Usage And Synthesis
Uses
Lisuride Maleate is a dopamine receptor agonist with additionally serotoninergic, adrenergic, and glutamate antagonistic properties. Treatment of Parkinsonism and other diseases associated with high level of prolactin.
in vivo
Lisuride (maleate) (0.78 and 3.13 mg/kg; i.p.; p.o.) is 3-4 times more potent on i.p. than on p.o. [2].
Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) antagonizes the motor depression and hypothermia induced by reserpine[2].
Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) is about as effective as apomorphine and D-amphetamine and causes significant hypothermia measured after dosages as low as 0.10 mg/kg i.p.[2].
| Animal Model: | NMRI mice (18-25 g)[2] |
| Dosage: | 0.78 and 3.13 mg/kg |
| Administration: | i.p., p.o. |
| Result: | Been 3-4 times more potent on i.p. than on p.o.. |
storage
Store at RT
R-(+)-LISURIDE HYDROGEN MALEATESupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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EMMX Biotechnology LLC
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INTERCHEMIE NANJING PHARMATECH CO., LTD
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Shanghai Zhibang Biological Medicine Co., LTD
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Zhengzhou Acme Chemical Co., Ltd.
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