MITOQ Chemical Properties

storage temp. 

-20°

solubility 

Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL)

form 

waxy solid

color 

Brown

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

MITOQ Usage And Synthesis

Description

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.

Uses

Mitoquinone is a mitochondria-targeted antioxidant.

References

[1] ANAMITRA GHOSH . Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model[J]. Free Radical Biology and Medicine, 2010, 49 11: Pages 1674-1684. DOI:10.1016/j.freeradbiomed.2010.08.028
[2] MEAGAN J MCMANUS J L F Michael P Murphy. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease.[J]. Journal of Neuroscience, 2011, 31 44: 15703-15715. DOI:10.1523/jneurosci.0552-11.2011
[3] SANGBIN LIM. Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity.[J]. Cellular Physiology and Biochemistry, 2011, 28 5: 873-886. DOI:10.1159/000335802
[4] JULIE DEMERS-LAMARCHE. Loss of Mitochondrial Function Impairs Lysosomes.[J]. Nuclear Fusion, 2016, 55 1: 10263-10276. DOI:10.1074/jbc.m115.695825
[5] JIAN ZHOU. Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway.[J]. American journal of translational research, 2018, 10 6: 1887-1899.
[6] LI XIAO . The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1[J]. Redox Biology, 2017, 11: Pages 297-311. DOI:10.1016/j.redox.2016.12.022
[7] DENG F, SHARMA I, DAI Y, et al. Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule.[J]. The Journal of clinical investigation, 2019, 42 1: 0. DOI:10.1172/jci129903

MITOQ(444890-41-9)Related Product Information

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• IWP-2