MITOQ Chemical Properties

storage temp. 

-20°

solubility 

Soluble in DMSO (70 mg/mL); ethanol (30 mg/mL)

form 

waxy solid

color 

Brown

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

MITOQ Usage And Synthesis

Description

Mitoquinone (444890-40-9) is a mitochondria-targeted antioxidant. Displays cardio- and neuroprotective effects.1?Displays beneficial effects in mouse models of Alzheimer’s disease.2?Mitoquinone protects pancreatic β-cells against oxidative stress and improves insulin secretion.3 Cell permeable.? Mesylate salt (Cat# 10-3914)and mesylate cyclodextrin complex (Cat# 10-3915) are also available.

Uses

Mitoquinone is a mitochondria-targeted antioxidant.

References

1) Ghosh et al. (2010), Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model; Free Radic. Biol. Med., 49 1674 2) McManus et al. (2011), The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease; J. Neurosci., 31 15703 3) Lim et al. (2011), Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity; Cell Physiol. Biochem., 28 873 4) Demers-Lamarche et al. (2016) Loss of Mitochondrial Function Impairs Lysosomes; J. Biol. Chem. 291 10263 [Focus Citation] 5) Zhou et al. (2018) Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway; Am. J. Transl. Res., 10 1887 [Focus Citation] 6) Xiao et al. (2017) The mitochondrial-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1; Redox Biol., 11 297 [Focus Citation] 7) Deng et al. (2019), Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule; J. Clin. Invest., 129 5033 [Focus Citation]

MITOQ(444890-41-9)Related Product Information

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• 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
• N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE
• IWP-2