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4-Nitrophenyl chloroformate

Basic information Safety Supplier Related

4-Nitrophenyl chloroformate Basic information

Product Name:
4-Nitrophenyl chloroformate
Synonyms:
  • 4-Nitrophenyl chloridocarbonate
  • CARBONOCHLORIDIC ACID, 4-NITROPHENYL ESTER
  • CHLOROFORMIC ACID 4-NITROPHENYL ESTER
  • CHLOROFORMIC ACID P-NITROPHENYL ESTER
  • 4-NITROPHENYL CHLOROCARBONATE
  • 4-NITROPHENYL CHLOROFORMATE
  • Nitrophenyl chloroforMate
  • 4-Nitrophenyl chloroforMate, 97% 25GR
CAS:
7693-46-1
MF:
C7H4ClNO4
MW:
201.56
EINECS:
231-706-9
Product Categories:
  • Pharmaceutical intermediates
  • Protection & Derivatization Reagents (for Synthesis)
  • blocks
  • BuildingBlocks
  • NitroCompounds
  • Synthetic Organic Chemistry
  • Miscellaneous
Mol File:
7693-46-1.mol
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4-Nitrophenyl chloroformate Chemical Properties

Melting point:
77-79 °C(lit.)
Boiling point:
159-162 °C19 mm Hg(lit.)
Density 
1.5719 (rough estimate)
refractive index 
1.6000 (estimate)
Flash point:
>110°C
storage temp. 
2-8°C
solubility 
Soluble in acetone, chloroform, acetone, toluene and benzene.
form 
isopropanol suspension
color 
White to yellow-beige
Water Solubility 
decomposes
Sensitive 
Lachrymatory
BRN 
518127
Stability:
Stable. Incompatible with strong bases, acids. Combustible.
CAS DataBase Reference
7693-46-1(CAS DataBase Reference)
NIST Chemistry Reference
Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
EPA Substance Registry System
Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)
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Safety Information

Hazard Codes 
C,T,Xi,F
Risk Statements 
34-36/37-23/24/25-41-36/37/38-11-67-36
Safety Statements 
26-36/37/39-45-38-28A-36-16-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
19-21
Hazard Note 
Toxic/Corrosive/Lachrymator
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159020

MSDS

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4-Nitrophenyl chloroformate Usage And Synthesis

Chemical Properties

Cream solid

Uses

4-Nitrophenyl Chloroformate is an ester of chloroformic acid used in the immobilization of enzymes and other biomolecules.

Uses

4-Nitrophenyl chloroformate is used in the synthesis of poly(oxyethylene) modified dextrans. It is also used to prepare a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA. Further, it is used in the synthesis of mixed, activated carbonates, thiocarbonates and activated urethanes. In addition to this, it is used in the preparation of 4-nitrophenyl diazoacetate with diazomethane.

Uses

4-Nitrophenyl chloroformate can be used:

  • As a reagent for the activation of amines, alcohols and thiols.
  • In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
  • In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
  • In the preparation of poly(oxyethylene) modified dextrans.
  • To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

4-Nitrophenyl chloroformateSupplier

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