5-Bromo-3-pyridinecarboxaldehyde Chemical Properties

Melting point:

98-102 °C

Boiling point:

251.1±20.0 °C(Predicted)

Density 

1.683±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

1.07±0.20(Predicted)

form 

Crystalline Powder

color 

White to off-white

Sensitive 

Air Sensitive

InChI

InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

InChIKey

NGUVGKAEOFPLDT-UHFFFAOYSA-N

SMILES

C1=NC=C(Br)C=C1C=O

CAS DataBase Reference

113118-81-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36/38-43

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

5-Bromo-3-pyridinecarboxaldehyde Usage And Synthesis

Uses

5-Bromonicotinaldehyde (5-Bromo-3-pyridinecarboxaldehyde) can replace anilines (anilines) compounds and is used in the synthesis of naphthyridines and diazobenzenes[1].

Synthesis

5-Bromo-3-pyridinecarboxaldehyde can be used as a pharmaceutical and chemical synthesis intermediate. In the existing technology, its synthesis method is to use 3,5-dibromo pyridine as raw material and exchange it with butyllithium bromide under ultra-low temperature (-78°C) conditions to prepare 5-Bromo-3-pyridinecarboxaldehyde. Or use 3,5-dibromopyridine as raw material and combine butyllithium and n-butylmagnesium chloride at -15°C to synthesize the product.

References

[1] European Journal of Medicinal Chemistry, 2006, vol. 41, # 7, p. 847 - 861
[2] Tetrahedron Letters, 2001, vol. 42, # 29, p. 4841 - 4844
[3] Patent: CN107628990, 2018, A. Location in patent: Paragraph 0020; 0021; 0038; 0039; 0040; 0041; 0042-0046
[4] Patent: US2013/65905, 2013, A1. Location in patent: Paragraph 0189
[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 77

5-Bromo-3-pyridinecarboxaldehyde (113118-81-3)Related Product Information

• 1-Hexadecylpyridinium bromide
• 3-Hydroxypyridine
• 3-Aminopyridine
• 3-Pyridyl bromide
• 4-Pyridinecarboxaldehyde
• 2-Chloro-3-cyanopyridine
• 3-Bromo-5-methylpyridine
• 2-Pyridinecarboxaldehyde
• 1-Bromododecane
• 3-Pyridinecarboxaldehyde
• (5-BROMO-PYRIDIN-3-YL)-METHANOL
• 3-Fluoro-6-bromo-2-pyridinecarboxaldehyde
• ,5-Dihydro-5-methyl-6-[4-(4-oxo-1(4H)-pyridinyl)phenyl]-1,2,4-triazin-3(2H)-one
• 2-BROMO-5-FORMYLPYRIDINE,2-BROMO-5-FORMYLPYRIDINE97+%,2-BROMO-5-PYRIDINECARBOXALDEHYDE,6-BROMO-3-PYRIDINECARBOXALDEHYDE
• Bromine
• 2,5-DIBROMONICOTINALDEHYDE
• 5-Bromopyridine-2-carbaldehyde
• 6-BROMO-2-FORMYLPYRIDINE,2-BROMO-6-FORMYLPYRIDINE