1-(2-Pyridyl)piperazine Chemical Properties

Melting point:

92-94

Boiling point:

120-122 °C/2 mmHg (lit.)

Density 

1.072 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.595(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in Chloroform, Methanol.

form 

Liquid

pka

8.63±0.10(Predicted)

color 

Clear colorless to yellow

Water Solubility 

>500 g/L (20 ºC)

Sensitive 

Air Sensitive

BRN 

140423

CAS DataBase Reference

34803-66-2(CAS DataBase Reference)

NIST Chemistry Reference

1-(2-Pyridyl)piperazine(34803-66-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

2735

WGK Germany 

3

F 

10-34

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

II

HS Code 

29339900

MSDS

• Language:English Provider:1-(2-Pyridyl)piperazine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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1-(2-Pyridyl)piperazine Usage And Synthesis

Chemical Properties

clear colourless to yellow liquid

Uses

1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli te of Azaperone (A802200).

Uses

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

General Description

1-(2-Pyridyl)piperazine is a piperazine derivative.

Synthesis

Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield.

References

[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50

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