Tiludronic acid Chemical Properties

Melting point:

174-177 °C

Boiling point:

600.7±65.0 °C(Predicted)

Density 

1.82±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

H2O: >10mg/mL, clear

pka

pK1 10.85; pK2 6.90; pK3 2.95; pK4 1.30(at 25℃)

form 

powder

color 

white to off-white

Water Solubility 

H2O: >10mg/mL, clear

Safety Information

WGK Germany 

3

Tiludronic acid Usage And Synthesis

Chemical Properties

pKl 10.85; pK2 6.90; pK3 2.95; pKa 41.30. Tiludronic Acid Di-tert-butylamine Salt: melting point 253°C (decomposition).

Definition

ChEBI: Tiludronic acid is an organochlorine compound.

Biological Activity

Tiludronate is a bisphosphonate bone resorption inhibitor. Tiludronate inhibits protein-tyrosine-phosphatase, leading to detachment of osteoclasts from the bone surface. It also inhibits the osteoclastic proton pump and is used to tre at Pagetμs disease.

Veterinary Drugs and Treatments

Tiludronate disodium (tiludronic acid) is a bisphosphonate bone resorption inhibitor that is available in some countries for the intravenous treatment of navicular disease in horses. Treatment earlier in the course of the disease apparently results in greater efficacy.
For humans, there is an orally administered FDA-approved product for treating Paget’s disease (osteitis deformans).

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