Ioversol Chemical Properties

Melting point:

180-182°C

Boiling point:

864.9±65.0 °C(Predicted)

Density 

d37 1.371 (c = 320 mgI/ml)

storage temp. 

Refrigerator

solubility 

DMSO (Sparingly), Methanol (Slightly)

pka

11.34±0.46(Predicted)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

87771-40-2(CAS DataBase Reference)

Safety Information

HS Code 

2924296000

Toxicity

LD50 in mice, rats, rabbits, dogs (gI/kg): 17, 15, >25, >12 i.v.; in male, female rats (mgI/kg): 1000, >1200 intracisternally (Ralston)

MSDS

• Language:English Provider:N,N'-Bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-(2-hydroxyethyl)amino]-2,4,6-triiodo-benzene-1,3-dicarboxamide

Ioversol Usage And Synthesis

Description

Loversol is a kind of organioiodine compound that used as a contrast medium. It has high iodine content as well as several hydrophilic groups. It can be used for peripheral and coronary arteriography and left ventriculograpy, cardiovascular system angiography, cerebral angiography, venography, tomographic imaging of the head and body as well as intravenous excretory urography. It takes effects through opacifying those vessels in the path of the flow of the contrast medium, permitting radiographic visualization of the internal structure.

References

http://www.rxlist.com/optiray-injection-drug.htm
https://www.drugbank.ca/drugs/DB09134

Chemical Properties

White Solid

Uses

Loversol is a radiopaque contrast agent. Ioversol contains iodine, a substance that absorbs x-rays. Contrast agents are used to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on a CT scan or other radiologic (x-ray) examination.

Uses

Nonionic, low osmolality, radiographic contrast agent. Diagnostic aid (radiopaque medium).

Definition

Loversol is classified as an organoiodine compound and is used as a contrast dye in diagnostic procedures. It contains high levels of iodine in addition to various hydrophilic groups.

brand name

Optiray (Mallinckrodt).

General Description

Ioversol is a low-osmolar, nonionicmonomer with 47% bound iodine content. It is indicated forangiography, excretory urography, ventriculography, andvarious CT procedures.

Side effects

The most common reaction is nausea, occurring at a rate of 1 percent.
Serious adverse reactions have been reported during post-approval use of Optiray. These serious adverse reactions include but are not limited to: anaphylactic reactions, arrhythmias, temporary blindness, tongue edema, seizures, respiratory arrest, bronchospasm, laryngeal spasm and thrombosis.

Ioversol(87771-40-2)Related Product Information

• N-ACETYL-L-TYROSINE ETHYL ESTER
• 1-Bromo-4-iodobenzene
• ALTRENOGEST
• N,N-Diisopropylethylamine
• Haloperidol
• N1,N3-Bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanamido)-2,4,6-triiodoisophthalamide
• 4-Iodoanisole
• Betaine
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• (Diacetoxyiodo)benzene
• Iodixanol
• 2-(METHYLSULFONYL)ETHANOL
• Glycine
• 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
• 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
• Iohexol
• N-DesMethyl IoMeprol
• IOMEPROL